| Joanna Barnes | Claudia Marius |
| Peter Brocco | Ramon |
| Tony Curtis | Antoninus |
| John Dall | Glabrus |
| Nicholas Dennis | Dionysius |
| Kirk Douglas | Spartacus |
| Nina Foch | Helena Glabrus |
| John Gavin | Julius Caesar |
| Anthony Hopkins (voice) | Marcus Licinius Crassus (some scenes,1991 restoration) |
| John Hoyt | Caius |
| John Ireland | Crixus |
| Paul Lambert | Gannicus |
| Charles Laughton | Lentulus Gracchus |
| Herbert Lom | Tigranes |
| David Lummis | Symmachus |
| Charles McGraw | Marcellus |
| Laurence Olivier | Marcus Licinius Crassus |
| Jean Simmons | Varinia |
| Harold J. Stone | David |
| Woody Strode | Draba |
| Peter Ustinov (S:AA) | Lentulus Batiatus |
| Robert J. Wilke | Guard Captain |
| Frederick Worlock | Laelius |